Stability evaluation of celecoxib nanoemulsion containing Tween 80
نویسندگان
چکیده
The aim of the present study was to evaluate the stability of celecoxib (CXB) using novel nanoemulsion formulation. Optimized nanoemulsion formulation of CXB was prepared by low energy emulsification method. Stability studies were performed for the period of 3 months. Droplet size, viscosity and refractive index (RI) were determined during storage. Shelf life of nanoemulsion formulation was also determined by accelerated stability testing. It was found that droplet size viscosity and RI were slightly increased at refrigerator and room temperature. The changes in these parameters were not significant (p ≥ 0.05). The shelf life of nanoemulsion formulation was found to be 2.73 years at room temperature. These results indicated that stability of CXB can be enhanced in nanoemulsion formulation using Tween 80 as surfactant.
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